Drug nutrient interaction defines a physicochemical, physiological, or pathophysiological association between medications and nutrients. These chemical reactions can contribute to malnutrition, interfere with medication therapy, and produce adverse events to include life threatening conditions. Furthermore, while micronutrient supplementation is warranted in those individuals who cannot meet their nutritional needs with food alone, the indiscriminate use of nutrient supplementation for disease prevention is not supported by the current scientific evidence. Registered dietitian nutritionists must be poised to evaluate the benefits and adverse outcomes of nutrient/dietary supplementation. RDNs must coordinate with the interprofessional team which includes physicians, physician assistants, nurse practitioners, pharmacists, nurses, and other healthcare providers to lessen drug nutrient interactions and adverse events.